2565: Localized immunosuppression in vascular composite allotransplantation using hydrogel drug delivery system
نویسندگان
چکیده
منابع مشابه
Site-Specific Immunosuppression in Vascularized Composite Allotransplantation: Prospects and Potential
Skin is the most immunogenic component of a vascularized composite allograft (VCA) and is the primary trigger and target of rejection. The skin is directly accessible for visual monitoring of acute rejection (AR) and for directed biopsy, timely therapeutic intervention, and management of AR. Logically, antirejection drugs, biologics, or other agents delivered locally to the VCA may reduce the n...
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Although organ and tissue transplantation has been a fantasy for centuries, the epidemic of discovery in transplantation has taken place primarily during the past 55 years. In 1954, Dr J. Murray was presented with the unique opportunity to transplant a human kidney between identical twins without facing the challenges of acute or chronic allograft rejection as well as side effects of long-term ...
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Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full factorial design was applied to optimize the concentration of chitosan and HPMC. T...
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Chitosan obtained by alkaline deacetylation of chitin is a non-toxic, biocompatible, and biodegradable natural polymer. Chitosan-based hydrogel polymeric beads have been extensively studied as microor nano-particulate carriers in the pharmaceutical and medical fields, where they have shown promise for drug delivery as a result of their controlled and sustained release properties, as well as bio...
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ژورنال
عنوان ژورنال: Vascularized Composite Allotransplantation
سال: 2016
ISSN: 2372-3505,2372-3513
DOI: 10.1080/23723505.2016.1233016